Inspired by nature, moved by science. Extremophiles from the volcanoes of the Andes and the glaciers of Patagonia form the proprietary genetic databases used to develop our new proteases and glycosidases. Don’t lose track!
Trypsin is a serine endopeptidase, which selectively cleaves peptide bonds C-terminal to lysine and arginine residues. In Blikk-Tryp, lysine residues have been chemically modified to avoid autolytic digestion. In addition, Blikk-Tryp is treated with L-(tosylamido-2-phenyl) ethyl chloromethyl ketone (TPCK) to inactivate any remaining chymotryptic activity. Combined with the high purification process, these features allow Blikk-Tryp to be used for bottom up proteomic analysis.
PNGase F is a recombinant N-Glycosidase F cloned from Elizabethkingia mirícola and expressed in E. coli. Blikk-Npep catalyzes the cleavage between the innermost N-Acetylglucosamine (GlcNAc) and asparagine residues of high mannose, hybrid, and complex oligosaccharides from N-linked glycoproteins. The specificity and high purity allow Blikk-Npep to be used for quality control in the manufacturing of monoclonal antibodies and for glycoprotein characterization. Blikk-Npep is supplied in two formats: 50% glycerol and glycerol free to facilitate handling.
α1-2 Fucosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of linear α1-2 linked fucose residues from oligosaccharides. Blikk-a1-2 Fuco cleaves the fucose sugar in the Fc region of immunoglobulin G1 for the production of afucosylated antibodies to improve the efficacy of therapeutic monoclonal antibodies.
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At Kura Biotech, our dedication is grounded in the strong belief and conviction that we can generate a positive impact in the World, by helping laboratories with their most complex challenges, and by providing scientists with the fastest and the highest performing enzymes for sample preparation.
After developing revolutionary solutions in toxicology through our Finden brand, we are now expanding our expertise to the genetics and proteomics industry with two new brands: Avenire and Blikka.
We thrive to face challenges through our four core commitments: human connections, unlimited spirit, unapologetic standards, and give back will.